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AZSMO-23

Chemical Structure : AZSMO-23

CAS No.: 496793-75-0

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AZSMO-23 (AZSMO 23;AZSMO23)

Catalog No.: PC-60836Not For Human Use, Lab Use Only.

AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.
    AZSMO-23 increases pre-pulse current at +40 mV by 952% and tail current at −30 mV by 238% at 100 uM.
    AZSMO-23 blocks the mutant channel hERG Y652A, but shows enhanced activator activity against another mutant channel hERG F656T.
    AZSMO-23 also blocks hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activated hCav1.2/β2/α2δ channels.

    Physicochemical Properties

    M.Wt 348.79
    Formula C19H13ClN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[3-(1H-benzimidazol-2-yl)-4-chloro-phenyl]pyridine-3-carboxamide

    References

    1. Mannikko R, et al. Br J Pharmacol. 2015 Jun;172(12):3112-25.

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