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Abafungin

Chemical Structure : Abafungin

CAS No.: 129639-79-8

Abafungin (BAY-W-6341)

Catalog No.: PC-28055Not For Human Use, Lab Use Only.

Abafungin (BAY-W-6341) is an arylguanidine antifungal compound with potent antifungal activity via inhibiting sterol-C-24 methyltransferase, Abafungin is a potent inhibitor of ergosterol biosynthesis in C. albicans at 0.01-1 mg/L, inhibits specifically the transmethylation of the sterol side chain.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Abafungin (BAY-W-6341) is an arylguanidine antifungal compound with potent antifungal activity via inhibiting sterol-C-24 methyltransferase, Abafungin is a potent inhibitor of ergosterol biosynthesis in C. albicans at 0.01-1 mg/L, inhibits specifically the transmethylation of the sterol side chain.

Physicochemical Properties

M.Wt 378.49
Formula C21H22N4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(2-(2,4-Dimethylphenoxy)phenyl)-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine

References

1. Fugmann S, et al. Chemotherapy. 2008;54(4):245-59.

2. Abouelkhair AA, et al. Antimicrob Agents Chemother. 2026 Sep 2;70(9):e0059826.

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