Chemical Structure : Abbapolin 6
CAS No.:
Abbapolin 6
Catalog No.: PC-27574Not For Human Use, Lab Use Only.
Abbapolin 6 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Abbapolin 6 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1.
Abbapolin 6 potently engages PLK1 in cells as determined by an increase in PLK1 thermal stability at sub-micromolar doses, but not for PLK3.
Abbapolin 6 inhibits PC3 prostate cancer cells with IC50 of 2.3 uM in a 72-hour MTT assay.
Abbapolin 6 inhibits colony formation of PC3 cells with IC50 of 337 nM.
Abbapolin 6 causes PLK1 degradation with DC50 of 3.186 uM in PC3 cells (72 h).
Abbapolin 6 induces degradation of PLK1 protein in PC3 prostate cancer xenograft tumors, shows synergic effect in combination with enzalutamide in androgen resistant C4-2R cells.
Physicochemical Properties
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M.Wt
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435.46
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Formula
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C22H30NO6P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-methyl-5-(4-(octyloxy)benzamido)phenyl dihydrogen phosphate
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References
1. Merhej G, et al. bioRxiv [Preprint]. 2026 Jul 24:2026.07.02.736204.
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