Chemical Structure : Abbapolin 8
CAS No.:
2803565-64-0
Abbapolin 8
Catalog No.: PC-27575Not For Human Use, Lab Use Only.
Abbapolin 8 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Abbapolin 8 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1.
Abbapolin 8 potently engages PLK1 in cells as determined by an increase in PLK1 thermal stability at sub-micromolar doses, but not for PLK3.
Abbapolin 8 inhibits PC3 prostate cancer cells with IC50 of 3.41 uM in a 72-hour MTT assay.
Abbapolin 8 inhibits colony formation of PC3 cells with IC50 of 6.28 uM.
Abbapolin 8 causes PLK1 degradation with DC50 of 5.005 uM in PC3 cells (72 h).
Abbapolin 8 induces degradation of PLK1 protein in PC3 prostate cancer xenograft tumors, shows synergy effect in combination with enzalutamide.
Physicochemical Properties
|
M.Wt
|
368.48
|
|
Formula
|
C22H28N2O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(4-(heptylamino)benzamido)-5-methylbenzoic acid
|
References
1. Merhej G, et al. bioRxiv [Preprint]. 2026 Jul 24:2026.07.02.736204.
Contact Us
sales@probechem.com
