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Abciximab

Chemical Structure : Abciximab

CAS No.:

Abciximab (Anti-human GPIIb/IIIa mAb, human IgG1 Fab-Kappa; c7E3 Fab)

Catalog No.: PC-Ab1095Not For Human Use, Lab Use Only.

Abciximab (Abcixifiban.

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Biological Activity

Abciximab (Abcixifiban; c7E3 Fab) is a monoclonal anti-glycoprotein IIb/IIIa receptor antibody antagonist, prevents platelet aggregation by blocking glycoprotein IIb/IIIa receptors on their platelet's plasma membrane and inhibits fibrinogen binding. It exerts it`s action by steric hindrance of the receptor itself and prevents platelet aggregation and subsequent thrombus formation and blocking interaction of fibrinogen. It also inhibits vitronectin receptor which mediates both platelet coagulation as well as endothelial and vascular smooth muscle proliferation.

Physicochemical Properties

M.Wt
Formula Human IgG1 Fab-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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