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Chemical Structure : Acalabrutinib
CAS No.: 1420477-60-6
Catalog No.: PC-45383Not For Human Use, Lab Use Only.
Acalabrutinib (ACP-196) is a potent, irreversible, covalent second-generation BTK inhibitor with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Acalabrutinib (ACP-196) is a potent, irreversible, covalent second-generation BTK inhibitor with IC50 of 3 nM.
Acalabrutinib (ACP-196) is more potent and selective than ibrutinib, and does not inhibit EGFR, Itk or Txk.
Acalabrutinib (ACP-196) inhibits tyrosine phosphorylation of downstream targets of ERK, IKB, and AKT, in the in vitro signaling assay on primary human CLL cells.
Acalabrutinib (ACP-196) inhibits anti-IgM-induced CD86 expression in CD19+ splenocytes with an ED50 of 0.34 mg/kg in mice.
Acalabrutinib (ACP-196) has promising safety and efficacy profiles for CLL treatment; orally active.
| M.Wt | 465.5065 | |
| Formula | C26H23N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl- |
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1. Byrd JC, et al. N Engl J Med. 2016 Jan 28;374(4):323-32.
2. Herman SEM, et al. Clin Cancer Res. 2017 Jul 15;23(14):3734-3743.
3. Niemann CU, et al. Clin Cancer Res. 2017 Jun 23. pii: clincanres.0650.2017.
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