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Acebilustat

Chemical Structure : Acebilustat

CAS No.: 943764-99-6

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Acebilustat (CTX-4430;EP-501)

Catalog No.: PC-45393Not For Human Use, Lab Use Only.

Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.

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100 mg $488 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.
Acebilustat (CTX-4430, EP-501) a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases.

Physicochemical Properties

M.Wt 481.5424
Formula C29H27N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO; Methanol: ≥ 32 mg/mL
Chemical Name/SMILES

Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-

References

1. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):20-27.

2. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):28-34.

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