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Chemical Structure : Acelarin
CAS No.: 840506-29-8
Catalog No.: PC-42285Not For Human Use, Lab Use Only.
Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance.
NUC-1031 is significantly less dependent on deoxycytidine kinase and on nucleoside transporters, and it is resistant to cytidine deaminase-mediated degradation compared with gemcitabine.
Acelarin (NUC-1031, CPF-31) inhibits L1210 and BxPC-3 cell proliferation with IC50 of 35 nM and 150 nM, respectively.
Acelarin (NUC-1031, CPF-31) significantly reduces tumor volumes in vivo in pancreatic cancer xenografts.
| M.Wt | 580.4744484 | |
| Formula | C25H27F2N4O8P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
L-Alanine, N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-, phenylmethyl ester |
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1. Slusarczyk M, et al. J Med Chem. 2014 Feb 27;57(4):1531-42.
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