Acetazolamide | CA IX inhibitor | Probechem Biochemicals

Chemical Structure : Acetazolamide

CAS No.: 59-66-5

Acetazolamide (AAZ)

Catalog No.: PC-22967Not For Human Use, Lab Use Only.

Acetazolamide is a potent carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX.

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Biological Activity

Acetazolamide is a potent carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX.
Acetazolamide inhibits the invasiveness of renal cell carcinoma in vitro by blocking hCA IX activity.
Acetazolamide shows diuretic, antihypertensive and anti-gonococcal activities.

Physicochemical Properties

M.Wt	222.24
Formula	C4H6N4O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetazolamide

References

1. Hou Z, et al. Eur J Med Chem. 2017 May 26;132:1-10.

2. Gao H, et al. Oncol Lett. 2018 Jun;15(6):9299-9306.

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Acetazolamide (AAZ)

Biological Activity

Physicochemical Properties

References

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