Chemical Structure : Acumapimod
CAS No.: 836683-15-9
Catalog No.: PC-45059Not For Human Use, Lab Use Only.
An orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM).
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Acumapimod (BCT-197) is an orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM).
Acumapimod (BCT-197) inhibits LPS‐stimulated TNFα release in the human whole blood assay with IC50 of 24 nM.
Acumapimod (BCT-197) shows antiinflammatory activity for treatment of acute as opposed to chronic inflammation disorders.
M.Wt | 385.4185 | |
Formula | C22H19N5O2 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: 10 mM |
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Chemical Name/SMILES |
Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl- |
1. De Buck S, et al. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.
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