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Acumapimod

Chemical Structure : Acumapimod

CAS No.: 836683-15-9

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Acumapimod (BCT-197, BCT197)

Catalog No.: PC-45059Not For Human Use, Lab Use Only.

An orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Acumapimod (BCT-197) is an orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM).
Acumapimod (BCT-197) inhibits LPS‐stimulated TNFα release in the human whole blood assay with IC50 of 24 nM.
Acumapimod (BCT-197) shows antiinflammatory activity for treatment of acute as opposed to chronic inflammation disorders.

Physicochemical Properties

M.Wt 385.4185
Formula C22H19N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: 10 mM
Chemical Name/SMILES

Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl-

References

1. De Buck S, et al. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.

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