Chemical Structure : Adavosertib
CAS No.:
955365-80-7
Adavosertib
(AZD-1775, MK-1775, AZD1775, MK1775)
Catalog No. : PC-42770Not For Human Use, Lab Use Only.
Adavosertib (AZD-1775;MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.
Packing Price Stock Quantity 10 mg $98 In stock 0 1 2 3 4 5 25 mg $158 In stock 0 1 2 3 4 5 50 mg $248 In stock 0 1 2 3 4 5 100 mg $398 In stock 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5 1 g Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4277001
Biological Activity
Adavosertib (AZD-1775, MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.
Physicochemical Properties
M.Wt
500.5954
Formula
C27H32N8O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
References
1. Hirai H, et al. Mol Cancer Ther.
2. Hirai H, et al. Cancer Biol Ther.
3. Bridges KA, et al. Clin Cancer Res.
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