Catalog No.: PC-73200Not For Human Use, Lab Use Only.
AdipoRon is an orally active, small-molecule adiponectin receptor (AdipoR) agonist, binds to both AdipoR1 and AdipoR2 wit Kd of 1.8 and 3.1 uM, respectively.
AdipoRon is an orally active, small-molecule adiponectin receptor (AdipoR) agonist, binds to both AdipoR1 and AdipoR2 wit Kd of 1.8 and 3.1 uM, respectively.
AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet.
AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet.
AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.
AdipoRon inhibits leptin induced pSTAT3 and in vivo pancreatic tumor growth.
