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Chemical Structure : Adomeglivant
CAS No.: 1488363-78-5
Catalog No.: PC-45745Not For Human Use, Lab Use Only.
A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $192 | In stock | |
| 50 mg | $352 | In stock | |
| 100 mg | $520 | In stock |
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A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM; displays >200-fold selectivity over related receptors; exhibits robust glucose-lowering in response to daily oral administration in an ob/ob mouse model of type 2 diabetes mellitus.
Diabetes
Phase 2 Discontinued
| M.Wt | 555.6277 | |
| Formula | C32H36F3NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 5.3 mg/mL |
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| Chemical Name/SMILES |
β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]- |
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1. Kelly RP, et al. Diabetes Obes Metab. 2015 Apr;17(4):414-22.
2. Grover S, et al. BMC Bioinformatics. 2014;15 Suppl 16:S13.
3. Kazda CM, et al. Diabetes Obes Metab. 2017 Aug;19(8):1071-1077.
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