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Adriforant

Chemical Structure : Adriforant

CAS No.: 943057-12-3

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Adriforant (PF-3893787,ZPL-3893787, ZPL-389, PF-03893787)

Catalog No.: PC-61567Not For Human Use, Lab Use Only.

Adriforant (PF-3893787, ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Adriforant (PF-3893787, ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM.
    Adriforant (PF-3893787, ZPL 3893787) has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation.
    Adriforant (PF-3893787, ZPL 3893787) exhibits anti-inflammatory activity.

    Physicochemical Properties

    M.Wt 262.361
    Formula C13H22N6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine

    References

    1. Mowbray CE, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.

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