Adriforant hydrochloride (PF-3893787, ZPL-3893787)

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Chemical Structure : Adriforant hydrochloride

Catalog No.: PC-28131Not For Human Use, Lab Use Only.

Adriforant hydrochloride (PF-3893787, ZPL-3893787) is a potent and selective histamine H4 receptor (H4R) antagonist with binding Ki of 2.4 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Adriforant hydrochloride (PF-3893787, ZPL-3893787) is a potent and selective histamine H4 receptor (H4R) antagonist with binding Ki of 2.4 nM.
Adriforant (PF-3893787, ZPL 3893787) has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation.
Adriforant (PF-3893787, ZPL 3893787) exhibits anti-inflammatory activity.

Physicochemical Properties

M.Wt	371.74
Formula	C13H25Cl3N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine hydrochloride

References

1. Mowbray CE, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.

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