Catalog No.: PC-42499Not For Human Use, Lab Use Only.
Afatinib (BIBW 2992) is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.
Afatinib (BIBW 2992) is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.
Afatinib (BIBW 2992) shows high selectivity over HGFR, c-Src, β-InsRK,VEGFR2.
Afatinib (BIBW 2992) suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines and induces tumor regression in xenograft and transgenic lung cancer models.
