Chemical Structure : AgrC inhibitor CP-20
CAS No.:
1448066-54-3
AgrC inhibitor CP-20
Catalog No.: PC-26393Not For Human Use, Lab Use Only.
AgrC inhibitor CP-20 is a specific small molecule inhibitor of quorum sensing receptor AgrC in Staphylococcus aureus with IC50 of 0.93 uM in group-I S. aureus transcriptional reporter assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AgrC inhibitor CP-20 is a specific small molecule inhibitor of quorum sensing receptor AgrC in Staphylococcus aureus with IC50 of 0.93 uM in group-I S. aureus transcriptional reporter assays.
AgrC inhibitor CP-20 could potentially target the AgrC sensor domain in both S. epidermidis and S. aureus (∼30–40% conserved across species).
CP-20 to completely inhibit P3 transcription (IC50 = 16 μM), strongly suggesting it targets either AgrC or AgrA.
CP-20 does not inhibit agr by directly preventing AgrA from binding to DNA, while directly inhibits AgrC autophosphorylation.
Physicochemical Properties
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M.Wt
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418.91
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Formula
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C18H15ClN4O2S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-chlorophenyl)-2-(thiophene-3-carboxamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxamide
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References
1. Polaske TJ, et al. J Am Chem Soc. 2026 Mar 11;148(9):9199-9204.
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