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AhR agonist ITE

Chemical Structure : AhR agonist ITE

CAS No.: 448906-42-1

AhR agonist ITE (ITE)

Catalog No.: PC-45600Not For Human Use, Lab Use Only.

AhR agonist ITE is a endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AhR agonist ITE is a endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro and in vivo.
AhR agonist ITE activates the murine AhR in vivo, but does not induce toxicity.
AhR agonist ITE induces the differentiation of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopic xenograft tumour models.

Physicochemical Properties

M.Wt 286.3058
Formula C14H10N2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester

References

1. Henry EC, et al. Toxicol Sci. 2010 Mar;114(1):90-100.

2. Wang K, et al. Cancer Lett. 2013 Oct 28;340(1):63-71.

3. Cheng J, et al. Nat Commun. 2015 Jun 10;6:7209.

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