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Alchemix

Chemical Structure : Alchemix

CAS No.: 281189-60-4

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Alchemix (ZP281M)

Catalog No.: PC-61356Not For Human Use, Lab Use Only.

Alchemix (ZP281M) is a dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Alchemix (ZP281M) is a dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.
    Alchemix (ZP281M) shows excellent antitumor activity in Adriamycin-resistant (2780AD) and cisplatin-resistant cell lines (IC50=19 nM) in vitro and in vivo.
    Alchemix (ZP281M) induces cell death independently of ATM and p53.

    Physicochemical Properties

    M.Wt 509.428
    Formula C24H30Cl2N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((2-(bis(2-chloroethyl)amino)ethyl)amino)-4-((2-(dimethylamino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione

    References

    1. Pors K, et al. Mol Cancer Ther. 2003 Jul;2(7):607-10.

    2. Pors K, et al. J Med Chem. 2004 Mar 25;47(7):1856-9.

    3. Thomas A, et al. Oncogene. 2015 Jun;34(25):3336-48.

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