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Chemical Structure : Alchemix
Catalog No.: PC-61356Not For Human Use, Lab Use Only.
A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.
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A dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer; shows excellent antitumor activity in Adriamycin-resistant (2780AD) and cisplatin-resistant cell lines (IC50=19 nM) in vitro and in vivo; induces cell death independently of ATM and p53.
| M.Wt | 509.428 | |
| Formula | C24H30Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pors K, et al. Mol Cancer Ther. 2003 Jul;2(7):607-10.
2. Pors K, et al. J Med Chem. 2004 Mar 25;47(7):1856-9.
3. Thomas A, et al. Oncogene. 2015 Jun;34(25):3336-48.
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