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Chemical Structure : Alectinib
CAS No.: 1256580-46-7
Catalog No.: PC-43320Not For Human Use, Lab Use Only.
Alectinib (CH5424802, AF-802) is a potent, selective ALK inhibitor with IC50 of 1.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg (Free Sample) | $28 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $178 | In stock | |
| 250 mg | $248 | In stock | |
| 1 g | Get quote |
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Alectinib (CH5424802, AF-802) is a potent, selective ALK inhibitor with IC50 of 1.9 nM.
Alectinib (CH5424802, AF-802) shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).
Alectinib (CH5424802, AF-802) exhibits anti-proliferative activity against NPM-ALK-positive cellline KARPAS-299 with IC50 of 3 nM.
Alectinib (CH5424802, AF-802) also inhibits mutant ALK F1174L and R1275Q with IC50 of 1 nM and 3.5 nM respectively; orally active.
| M.Wt | 482.6165 | |
| Formula | C30H34N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.2 mg/mL (Need warming) |
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| Chemical Name/SMILES |
5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo- |
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1. Kinoshita K, et al. Bioorg Med Chem. 2012 Feb 1;20(3):1271-80.
2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.
3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.
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