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Alectinib

Chemical Structure : Alectinib

CAS No.: 1256580-46-7

Alectinib (CH5424802;AF-802;CH 5424802;CH-5424802;AF802;AF 802)

Catalog No.: PC-43320Not For Human Use, Lab Use Only.

Alectinib (CH5424802, AF-802) is a potent, selective ALK inhibitor with IC50 of 1.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Alectinib (CH5424802, AF-802) is a potent, selective ALK inhibitor with IC50 of 1.9 nM.
Alectinib (CH5424802, AF-802) shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).
Alectinib (CH5424802, AF-802) exhibits anti-proliferative activity against NPM-ALK-positive cellline KARPAS-299 with IC50 of 3 nM.
Alectinib (CH5424802, AF-802) also inhibits mutant ALK F1174L and R1275Q with IC50 of 1 nM and 3.5 nM respectively; orally active.

Physicochemical Properties

M.Wt 482.6165
Formula C30H34N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.2 mg/mL (Need warming)

Chemical Name/SMILES

5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-

References

1. Kinoshita K, et al. Bioorg Med Chem. 2012 Feb 1;20(3):1271-80.

2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.

3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.

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