Alectinib hydrochloride | ALK inhibitor

Chemical Structure : Alectinib hydrochloride

CAS No.: 1256589-74-8

Catalog No.: PC-43321Not For Human Use, Lab Use Only.

Alectinib (CH5424802, AF-802) hydrochloride is a potent, selective ALK inhibitor with IC50 of 1.9 nM.

Packing	Price	Stock
10 mg (Free Sample)	$28	In stock
50 mg	$128	In stock
100 mg	$178	In stock
250 mg	$248	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Alectinib (CH5424802, AF-802) hydrochloride is a potent, selective ALK inhibitor with IC50 of 1.9 nM.

Alectinib (CH5424802, AF-802) shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM).

Alectinib (CH5424802, AF-802) exhibits anti-proliferative activity against NPM-ALK-positive cellline KARPAS-299 with IC50 of 3 nM.

Alectinib (CH5424802, AF-802) also inhibits mutant ALK F1174L and R1275Q with IC50 of 1 nM and 3.5 nM respectively; orally active.

M.Wt	519.0775
Formula	C30H35ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 6 mg/mL (Need ultrasonic or warming)
Chemical Name/SMILES	5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-, hydrochloride (1:1)

1. Kinoshita K, et al. Bioorg Med Chem. 2012 Feb 1;20(3):1271-80.

2. Sakamoto H, et al. Cancer Cell. 2011 May 17;19(5):679-90.

3. Kodama T, et al. Mol Cancer Ther. 2014 Dec;13(12):2910-8.