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Alflutinib

Chemical Structure : Alflutinib

CAS No.: 1869057-83-9

Alflutinib (AST2818, Furmonertinib, Firmonertinib)

Catalog No.: PC-35640Not For Human Use, Lab Use Only.

Alflutinib (Furmonertinib, AST-2818) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.

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Biological Activity

Alflutinib (Furmonertinib, AST-2818) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.

Physicochemical Properties

M.Wt 568.605
Formula C28H31F3N8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide

References

1. PCT Int. Appl. (2017), WO 2017152707 A1 20170914.

2. PCT Int. Appl. (2017), WO 2017152706 A1 20170914.

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