Chemical Structure : Aliskiren hemifumarate
CAS No.:
173334-58-2
Aliskiren hemifumarate
(CGP 60536;CGP60536B;SPP 100)
Catalog No.: PC-42906Not For Human Use, Lab Use Only.
Aliskiren (CGP60536B) hemifumarate is a first-in-class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM.
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| 50 mg | $118 | In stock | |
| 100 mg | $188 | In stock | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Aliskiren (CGP60536B) hemifumarate is a first-in-class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM.
Aliskiren shows no significant inhibition on Cathepsin D, Cathepsin E, Pepsin and HIV-1 peptidase (> 50 uM); orally bioactive.
Physicochemical Properties
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M.Wt
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1219.589
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Formula
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C64H110N6O16
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1)
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References
1. Wood JM, et al. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705.
2. Desjarlais M, et al. Atherosclerosis. 2015 Oct;242(2):450-60.
3. Jumar A, et al. J Hypertens. 2015 Dec;33(12):2491-9.
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