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Chemical Structure : Alisporivir
Catalog No.: PC-21261Not For Human Use, Lab Use Only.
Alisporivir (Debio 025, DEBIO-025) is a non-immunosuppressive cyclophilin inhibitor derived from cyclosporin A (CsA) with IC50 of 30 nM (CypD PPIase activity ), inhibits HCV replication in vitro more potently than CsA.
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Alisporivir (Debio 025, DEBIO-025) is a non-immunosuppressive cyclophilin inhibitor derived from cyclosporin A (CsA) with IC50 of 30 nM (CypD PPIase activity ), inhibits HCV replication in vitro more potently than CsA.
Alisporivir (Debio 025, DEBIO-025) inhibits HCV subgenomic replicon replication in Huh 5-2 cells (luciferase assay) with EC50 of 0.27 ug/mL.
Alisporivir (Debio 025, DEBIO-025) selectively inhibits the replication of HIV-1 in a CD4+ cell line and in peripheral blood mononuclear cells, interferes with the function of CypA during the progression/completion of HIV-1 reverse transcription.
Alisporivir (Debio 025, DEBIO-025) also blocks SARS-CoV and MERS-CoV replication.
| M.Wt | 1216.66 | |
| Formula | C63H113N11O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Flisiak R, et al. Hepatology. 2008 Mar;47(3):817-26.
2. Inoue K, et al. Hepatology. 2007 Apr;45(4):921-8.
3. Ptak RG, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17.
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