Chemical Structure : Allitinib
CAS No.:
897383-62-9
Allitinib
(AST-1306;ALS1306)
Catalog No. : PC-60010Not For Human Use, Lab Use Only.
Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6001001
Biological Activity
Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR HER2
Solid Tumors
Phase 1 Clinical
Physicochemical Properties
M.Wt
448.877
Formula
C24H18ClFN4O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide
References
1. Xie H, et al. PLoS One.
2. Zhang H, et al. Cancer Lett.
3. Zhang J, et al. J Hematol Oncol.
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