Chemical Structure : Alosetron
CAS No.:
122852-42-0
Alosetron
(GR-68755X, GR-68755)
Catalog No.: PC-45944Not For Human Use, Lab Use Only.
Alosetron (GR-68755) is a potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
Alosetron (GR-68755) is a potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.
Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 of ~55 nM.
Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.
Physicochemical Properties
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M.Wt
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294.351
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Formula
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C17H18N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-
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References
1. Audolfsson G, et al. Aliment Pharmacol Ther. 1999 May;13 Suppl 2:39-47.
2. Zhai J, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):374-82.
3. Saslow SB, et al. Gut. 1998 May;42(5):628-34.
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