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Aloxistatin

Chemical Structure : Aloxistatin

CAS No.: 88321-09-9

Aloxistatin (E64d, E64c ethyl ester, Loxistatin, Rexostatine)

Catalog No.: PC-42094Not For Human Use, Lab Use Only.

Aloxistatin (E64d) is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Aloxistatin (E64d) is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with the ability to inhibit calpain activity in intact platelets.
Aloxistatin (E64d) reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B.

Physicochemical Properties

M.Wt 342.4305
Formula C17H30N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 23 mg/mL

Chemical Name/SMILES

2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-

References

1. Ostrowski LE, et al. Cancer Res. 1986 Aug;46(8):4121-8.

2. Hook G, et al. J Alzheimers Dis. 2011;26(2):387-408.

3. McGowan EB, et al. Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5.

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