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Alvimopan

Chemical Structure : Alvimopan

CAS No.: 156053-89-3

Alvimopan (ADL 8-2698, LY246736)

Catalog No.: PC-43423Not For Human Use, Lab Use Only.

Alvimopan (LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Alvimopan (LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.
Alvimopan (LY 246736) prevents gastrointestinal effects of intravenous morphine without affecting analgesia.
Alvimopan (LY 246736) is orally active.

Physicochemical Properties

M.Wt 424.5326
Formula C25H32N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-

References

1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.

2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.

3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.

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