Chemical Structure : Amelparib hydrochloric hydrate
CAS No.:
1449233-60-6
Amelparib hydrochloric hydrate
(JPI-289;JPI289)
Catalog No.: PC-35442Not For Human Use, Lab Use Only.
Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.
Stroke
Phase 2 Clinical
Physicochemical Properties
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M.Wt
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452.373
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Formula
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C19H31Cl2N3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one dihydrochloride dihydrate
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References
1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679.
2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.
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