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Chemical Structure : Amelubant
Catalog No.: PC-63302Not For Human Use, Lab Use Only.
Amelubant (BIIL 284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist with Ki values of 221 nM and 230 nM in vital cells and membranes.
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Amelubant (BIIL 284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist with Ki values of 221 nM and 230 nM in vital cells and membranes.
Amelubant (BIIL 284) inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.).
Amelubant (BIIL 284) inhibits LTB(4)-induced transdermal chemotaxis in guinea pigs with ED50 of 0.03 mg/kg p.o.
| M.Wt | 538.644 | |
| Formula | C33H34N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Birke FW, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.
2. Döring G, et al. J Cyst Fibros. 2014 Mar;13(2):156-63.
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