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Amenamevir

Chemical Structure : Amenamevir

CAS No.: 841301-32-4

Amenamevir (ASP-2151, ASP2151)

Catalog No.: PC-60382Not For Human Use, Lab Use Only.

Amenamevir (ASP-2151) is a potent viral helicase-primase inhibitor that possesses antiviral activity against VZV, HSV1 and HSV2 with EC50 of 0.028-0.1 uM.

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Biological Activity

Amenamevir (ASP-2151) is a potent viral helicase-primase inhibitor that possesses antiviral activity against VZV, HSV1 and HSV2 with EC50 of 0.028-0.1 uM.
Amenamevir (ASP-2151) exerts equipotent activity against VZV, HSV-1 and HSV-2 through prevention of viral DNA replication.
Amenamevir (ASP-2151) also shows activity against aciclovir-resistant VZV.

Physicochemical Properties

M.Wt 482.555
Formula C24H26N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-((4-(1,2,4-oxadiazol-3-yl)phenyl)amino)-2-oxoethyl)-N-(2,6-dimethylphenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide

References

1. Chono K, et al. J Antimicrob Chemother. 2010 Aug;65(8):1733-41.

2. Himaki T, et al. Antiviral Res. 2012 Feb;93(2):301-4.

3. Katsumata K, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3587-91.

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