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Amgen16

Chemical Structure : Amgen16

CAS No.: 1202761-92-9

Amgen16 (Amgen 16)

Catalog No.: PC-35548Not For Human Use, Lab Use Only.

Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.

Physicochemical Properties

M.Wt 354.838
Formula C19H19ClN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((1-(2-amino-5-chloropyrimidin-4-yl)indolin-6-yl)ethynyl)cyclopentan-1-ol

References

1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66.

2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.

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