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Chemical Structure : Amgen16
Catalog No.: PC-35548Not For Human Use, Lab Use Only.
Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NF-kB activity is NIK-dependent.
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Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NF-kB activity is NIK-dependent.
IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitor in MMCLs with NIK-dependent NFkB activation. blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.
| M.Wt | 354.838 | |
| Formula | C19H19ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66.
2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.
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