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Amikacin

Chemical Structure : Amikacin

CAS No.: 37517-28-5

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Amikacin (BAY 41-6551)

Catalog No.: PC-25699Not For Human Use, Lab Use Only.

Amikacin (BAY 41-6551) is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells.

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100 mg $58 In stock
250 mg $88 In stock
500 mg $128 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Amikacin (BAY 41-6551) is an aminoglycoside antibiotic that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains (E. coli, MIC=512 ug/mL), induces thioredoxin-interacting protein (TXNIP) up-regulation and suppresses migration and invasion in MDA-MB-231 cells.

Physicochemical Properties

M.Wt 585.61
Formula C22H43N5O13
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-Amino-N-((1R,2S,3S,4R,5S)-5-amino-2-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide

References

1. Fattorini L, et al. Antimicrob Agents Chemother. 1998 Mar;42(3):712-4.

2. Wang YH, et al. Toxics. 2020 Nov 20;8(4):108.

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