Amiloride | ENaC inhibitor | Probechem Biochemicals

Chemical Structure : Amiloride

CAS No.: 2609-46-3

Amiloride (MK-870, MK870)

Catalog No.: PC-23672Not For Human Use, Lab Use Only.

Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC and urokinase-type plasminogen activator receptor (uTPA), also is a blocker of polycystin-2 (PC2, TRPP2) channel.

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Biological Activity

Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC and urokinase-type plasminogen activator receptor (uTPA), also is a blocker of polycystin-2 (PC2, TRPP2) channel.

Physicochemical Properties

M.Wt	229.63
Formula	C6H8ClN7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide

References

1. Ji, H.L., et al. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-2

2. Giamarchi A, et al. EMBO J. 2010 Apr 7;29(7):1176-91.

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Amiloride (MK-870, MK870)

Biological Activity

Physicochemical Properties

References

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