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Aminoflavone

Chemical Structure : Aminoflavone

CAS No.: 165179-35-1

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Aminoflavone (NSC-686288, NSC686288)

Catalog No.: PC-26119Not For Human Use, Lab Use Only.

Aminoflavone is a small molecule aryl hydrocarbon receptor (AhR) ligand, inhibits HIF-1alpha expression in an AhR-independent fashion, also inhibits α6-integrin expression and breast cancer sphere-initiating capacity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Aminoflavone is a small molecule aryl hydrocarbon receptor (AhR) ligand, inhibits HIF-1alpha expression in an AhR-independent fashion, also inhibits α6-integrin expression and breast cancer sphere-initiating capacity.

Physicochemical Properties

M.Wt 320.27
Formula C16H11F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methylchromen-4-one

References

1. Campbell PS, et al. J Cell Physiol. 2018 Jan;234(1):108-121.

2. Brantley E, et al. Cancer Lett. 2016 Jun 28;376(1):53-61.

3. Terzuoli E, et al. Cancer Res. 2010 Sep 1;70(17):6837-48.

4. Loaiza-Pérez AI, et al. Mol Cancer Ther. 2004 Jun;3(6):715-25.

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