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Amonafide

Chemical Structure : Amonafide

CAS No.: 69408-81-7

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Amonafide (AS1413, AS-1413)

Catalog No.: PC-42763Not For Human Use, Lab Use Only.

Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

Physicochemical Properties

M.Wt 283.3251
Formula C16H17N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-

References

1. Allen SL, et al. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003.

2. Zhu H, et al. Mol Cancer Ther. 2007 Feb;6(2):484-95.

3. Liang X, et al. Mol Cancer Res. 2010 Dec;8(12):1619-32.

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