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Amprenavir

Chemical Structure : Amprenavir

CAS No.: 161814-49-9

Amprenavir (VX-478;141W94)

Catalog No.: PC-45253Not For Human Use, Lab Use Only.

A potent HIV-1 protease inhibitor with IC50 of 80 nM, has mean IC50 of 12 nM against 6 HIV clinical isolates.

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Biological Activity

A potent HIV-1 protease inhibitor with IC50 of 80 nM, has mean IC50 of 12 nM against 6 HIV clinical isolates; shows synergistic effect with a variety of anti-HIV-1 agents and exhibits a unique cross resistance profile.

HIV Infection

Approved

Physicochemical Properties

M.Wt 505.6269
Formula C25H35N3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3S)-tetrahydro-3-furanyl ester

References

1. St Clair MH, et al. Antiviral Res. 1996 Jan;29(1):53-6.

2. Partaledis JA, et al. J Virol. 1995 Sep;69(9):5228-35.

3. Markland W, et al. J Virol. 2000 Aug;74(16):7636-41.

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