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Chemical Structure : AnCoA4
Catalog No.: PC-60194Not For Human Use, Lab Use Only.
AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.
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AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.
AnCoA4 binds to the C terminus of Orai1, directly inhibits calcium influx through the channel and also reduces binding of STIM1.
AnCoA4 decreased gene expression involved in T cell activation, including IL2, CD27, NFATC1, TNF, TBX21, CSF, ICOS, and CXCR3.
AnCoA4 effectively blocks T cell activation in vitro and in vivo.
| M.Wt | 378.37 | |
| Formula | C22H18O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sadaghiani AM, et al. Chem Biol. 2014 Oct 23;21(10):1278-92.
2. Sadaghiani AM, et al. Chem Biol. 2014 Oct 23;21(10):1278-1292.
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