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AnCoA4

Chemical Structure : AnCoA4

CAS No.: 24211-36-7

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AnCoA4 (AnCoA-4;Jamaicin)

Catalog No.: PC-60194Not For Human Use, Lab Use Only.

AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.
    AnCoA4 binds to the C terminus of Orai1, directly inhibits calcium influx through the channel and also reduces binding of STIM1.
    AnCoA4 decreased gene expression involved in T cell activation, including IL2, CD27, NFATC1, TNF, TBX21, CSF, ICOS, and CXCR3.
    AnCoA4 effectively blocks T cell activation in vitro and in vivo.

    Physicochemical Properties

    M.Wt 378.37
    Formula C22H18O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(6-methoxybenzo[d][1,3]dioxol-5-yl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one

    References

    1. Sadaghiani AM, et al. Chem Biol. 2014 Oct 23;21(10):1278-92.

    2. Sadaghiani AM, et al. Chem Biol. 2014 Oct 23;21(10):1278-1292.

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