Chemical Structure : Anacetrapib
CAS No.: 875446-37-0
Catalog No.: PC-42893Not For Human Use, Lab Use Only.
Anacetrapib (MK 0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9 nM and 11.8 nM for rhCETP and C13S CETP mutant, respectively.
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	Anacetrapib (MK-0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9 nM and 11.8 nM for rhCETP and C13S CETP mutant, respectively.
	Anacetrapib (MK-0859) inhibits CETP-mediated cholesterol exchange, resulting in elevated HDL-cholesterol levels and reductions in LDL-cholesterol levels.
	Anacetrapib (MK-0859)  demonstrates potential to treat elevated cholesterol levels in an effort prevent cardiovascular disease.
| M.Wt | 637.5084 | |
| Formula | C30H25F10NO3 | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             10 mM in DMSO  | 
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| Chemical Name/SMILES | 
                             2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl]-4-methyl-, (4S,5R)-  | 
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1. Krishna R, et al. Lancet. 2007 Dec 8;370(9603):1907-14.
2. Vergeer M, et al. Nat Clin Pract Cardiovasc Med. 2008 Jun;5(6):302-3.
3. Cannon CP, et al. Am Heart J. 2009 Oct;158(4):513-519.e3.
4. Niesor EJ, et al. J Lipid Res. 2010 Dec;51(12):3443-54.

                
                
                
                
                
                
                
                
            
            
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