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Chemical Structure : Anacetrapib
CAS No.: 875446-37-0
Catalog No.: PC-42893Not For Human Use, Lab Use Only.
Anacetrapib (MK 0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9 nM and 11.8 nM for rhCETP and C13S CETP mutant, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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Anacetrapib (MK-0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9 nM and 11.8 nM for rhCETP and C13S CETP mutant, respectively.
Anacetrapib (MK-0859) inhibits CETP-mediated cholesterol exchange, resulting in elevated HDL-cholesterol levels and reductions in LDL-cholesterol levels.
Anacetrapib (MK-0859) demonstrates potential to treat elevated cholesterol levels in an effort prevent cardiovascular disease.
| M.Wt | 637.5084 | |
| Formula | C30H25F10NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl]-4-methyl-, (4S,5R)- |
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1. Krishna R, et al. Lancet. 2007 Dec 8;370(9603):1907-14.
2. Vergeer M, et al. Nat Clin Pract Cardiovasc Med. 2008 Jun;5(6):302-3.
3. Cannon CP, et al. Am Heart J. 2009 Oct;158(4):513-519.e3.
4. Niesor EJ, et al. J Lipid Res. 2010 Dec;51(12):3443-54.
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