Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Others-CETP-Anacetrapib
Anacetrapib

Chemical Structure : Anacetrapib

CAS No.: 875446-37-0

Anacetrapib (MK-0859, MK0859)

Catalog No.: PC-42893Not For Human Use, Lab Use Only.

Anacetrapib (MK 0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9 nM and 11.8 nM for rhCETP and C13S CETP mutant, respectively.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $158 In stock
50 mg $258 In stock
100 mg $428 In stock
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Anacetrapib (MK-0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9 nM and 11.8 nM for rhCETP and C13S CETP mutant, respectively.
Anacetrapib (MK-0859) inhibits CETP-mediated cholesterol exchange, resulting in elevated HDL-cholesterol levels and reductions in LDL-cholesterol levels.
Anacetrapib (MK-0859)  demonstrates potential to treat elevated cholesterol levels in an effort prevent cardiovascular disease.

Physicochemical Properties

M.Wt 637.5084
Formula C30H25F10NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl]-4-methyl-, (4S,5R)-

References

1. Krishna R, et al. Lancet. 2007 Dec 8;370(9603):1907-14.

2. Vergeer M, et al. Nat Clin Pract Cardiovasc Med. 2008 Jun;5(6):302-3.

3. Cannon CP, et al. Am Heart J. 2009 Oct;158(4):513-519.e3.

4. Niesor EJ, et al. J Lipid Res. 2010 Dec;51(12):3443-54.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: