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Anastrozole

Chemical Structure : Anastrozole

CAS No.: 120511-73-1

Anastrozole (Arimidex, ZD1033, ZD-1033)

Catalog No.: PC-28394Not For Human Use, Lab Use Only.

Anastrozole (Arimidex, ZD1033) is a potent, highly selective, nonsteroidal aromatase inhibitor with IC50 of 15 nM for human placental aromatase, causes regression of breast carcinomas by reducing estrogen production via inhibition of aromatase (estrogen synthetase).

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Biological Activity

Anastrozole (Arimidex, ZD1033) is a potent, highly selective, nonsteroidal aromatase inhibitor with IC50 of 15 nM for human placental aromatase, causes regression of breast carcinomas by reducing estrogen production via inhibition of aromatase (estrogen synthetase).

Physicochemical Properties

M.Wt 293.37
Formula C17H19N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)

References

1. Geisler J, et al. Br J Cancer. 1996 Oct;74(8):1286-91.

2. Buzdar A, et al. J Clin Oncol. 1996 Jul;14(7):2000-11.

3. Dukes M, et al. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45.

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