Andamertinib | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : Andamertinib

Andamertinib (PLB1004, PLB-1004)

Catalog No.: PC-24110Not For Human Use, Lab Use Only.

Andamertinib (PLB1004, PLB-1004) is a potent, selective and irreversible inhibitor of EGFR exon 20 insertion mutations with IC50 values ranging from 25.67-316.6 nM.

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Biological Activity

Andamertinib (PLB1004, PLB-1004) is a potent, selective and irreversible inhibitor of EGFR exon 20 insertion mutations with IC50 values ranging from 25.67-316.6 nM.
PLB1004 also potently targets classical EGFR mutations ExDel19, L858R and T790M with a high degree of selectivity over wild-type EGFR.

Physicochemical Properties

M.Wt	568.68
Formula	C31H36N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methoxy-2-[4-(3-methoxyazetidin-1-yl)piperidin-1-yl]-5-{[6-(1 methyl-1H-indazol-5-yl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide

References

1. Jinji Yang, et al. Cancer Res (2023) 83 (8_Supplement): CT102.

2. Patent CN108707139 A.

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Andamertinib (PLB1004, PLB-1004)

Biological Activity

Physicochemical Properties

References

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