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Anguizole

Chemical Structure : Anguizole

CAS No.: 442666-98-0

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Anguizole (HCV NS4B inhibitor)

Catalog No.: PC-43491Not For Human Use, Lab Use Only.

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM.
Anguizole disrupts NS4B-AH2-mediated biological functions of NS4B, NS4B's dimerization/multimerization, its proper subcellular localization, as well as its interaction with NS5A.

Physicochemical Properties

M.Wt 408.81
Formula C17H11ClF2N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-

References

1. Choi M, et al. Virus Genes. 2013 Dec;47(3):395-407.

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