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Chemical Structure : Anle-138b
CAS No.: 882697-00-9
Catalog No.: PC-70278Not For Human Use, Lab Use Only.
Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn).
Emrusolmin (Anle-138b) strongly inhibits all prion strains tested including BSE-derived and human prions.
Emrusolmin (Anle-138b) binds to aggregated tau and inhibits tau aggregation in vitro and in vivo.
Emrusolmin (Anle-138b) has no detectable toxicity, excellent oral bioavailability and blood-brain-barrier penetration.
| M.Wt | 343.17 | |
| Formula | C16H11BrN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole |
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1. Turriani E, et al. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977.
2. Wagner J, et al. Acta Neuropathol. 2013 Jun;125(6):795-813.
3. Wagner J, et al. Acta Neuropathol. 2015 Nov;130(5):619-31.
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