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Anle-138b

Chemical Structure : Anle-138b

CAS No.: 882697-00-9

Anle-138b (Anle138b, Emrusolmin)

Catalog No.: PC-70278Not For Human Use, Lab Use Only.

Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn).
Emrusolmin (Anle-138b) strongly inhibits all prion strains tested including BSE-derived and human prions.
Emrusolmin (Anle-138b) binds to aggregated tau and inhibits tau aggregation in vitro and in vivo.
Emrusolmin (Anle-138b) has no detectable toxicity, excellent oral bioavailability and blood-brain-barrier penetration.

Physicochemical Properties

M.Wt 343.17
Formula C16H11BrN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole

References

1. Turriani E, et al. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977.

2. Wagner J, et al. Acta Neuropathol. 2013 Jun;125(6):795-813.

3. Wagner J, et al. Acta Neuropathol. 2015 Nov;130(5):619-31.

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