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Annamycin

Chemical Structure : Annamycin

CAS No.: 92689-49-1

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Annamycin (Naxtarubicin)

Catalog No.: PC-24967Not For Human Use, Lab Use Only.

Annamycin (Naxtarubicin) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo, intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Annamycin (Naxtarubicin) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo, intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis.

Physicochemical Properties

M.Wt 640.38
Formula C26H25IO11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione

References

1. Wetzler M, et al. Clin Lymphoma Myeloma Leuk. 2013 Aug;13(4):430-4.

2. Trevino AV, et al. Mol Cancer Ther. 2004 Nov;3(11):1403-10.

3. Perez-Soler R, et al. Int J Cancer. 1997 Mar 28;71(1):35-41.

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