Chemical Structure : Anrikefon acetate
CAS No.:
2584931-05-3
Anrikefon acetate
(HSK21542 acetate)
Catalog No.: PC-23827Not For Human Use, Lab Use Only.
Anrikefon (HSK21542) acetate is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 0.54 nM, and binding Kd of 0.068 nM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Anrikefon (HSK21542) acetate is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 0.54 nM, and binding Kd of 0.068 nM.
HSK21542 significantly inhibits forskolin-induced cAMP accumulation in HEK-293 cells that stably expressed human κ opioid receptor with an EC50 of 2.41 pM.
HSK21542 displays no significant affinity against a broad panel of receptors, ion channels, transporters and enzymes, including MOR and DOR.
HSK21542 significantly inhibits acetic acid-, hindpaw incision- or chronic constriction injury-induced pain-related behaviors in animal models of pain
Physicochemical Properties
|
M.Wt
|
763.98
|
|
Formula
|
C41H61N7O7
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
7-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-2-acetyl-2,7-diazaspiro (3.5)nonane acetate
|
References
1. Wang X, et al. Front Pharmacol. 2021 Nov 16;12:773204.
Contact Us
sales@probechem.com
