Chemical Structure : Ansamitocin P-3
CAS No.:
66547-09-9
Ansamitocin P-3
(Maytansinol butyrate)
Catalog No. : PC-45742Not For Human Use, Lab Use Only.
A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4574201
Biological Activity
A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.
Physicochemical Properties
M.Wt
635.1448
Formula
C32H43ClN2O9
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-
References
1. Ootsu K, et al. Cancer Res. 1980 May;40(5):1707-17.
2. Venghateri JB, et al. PLoS One. 2013 Oct 4;8(10):e75182.
3. Martin K, et al. Cancer Immunol Immunother. 2014 Sep;63(9):925-38.
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