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Ansornitinib

Chemical Structure : Ansornitinib

CAS No.: 1448874-96-1

Ansornitinib (ANG-3070, ANG3070)

Catalog No.: PC-49117Not For Human Use, Lab Use Only.

Ansornitinib (ANG-3070, ANG3070) is an oral fibrokinase inhibitor inhibitor of PDGFR and VEGFR/KDR with high binding affinity, also targets Discoidin Domain Receptors 1 and 2 (DDR1 and DDR2), tyrosine kinase receptors linked to the development of fibrosis in the kidneys and lungs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ansornitinib (ANG-3070, ANG3070) is an oral fibrokinase inhibitor inhibitor of PDGFR and VEGFR/KDR with high binding affinity, also targets Discoidin Domain Receptors 1 and 2 (DDR1 and DDR2), tyrosine kinase receptors linked to the development of fibrosis in the kidneys and lungs.
Ansornitinib (ANG-3070, ANG3070) exhibits limited interaction with other receptor tyrosine kinases
Ansornitinib (ANG-3070, ANG3070) has demonstrated beneficial effects in chronic kidney disease animal models.

Physicochemical Properties

M.Wt 540.624
Formula C30H32N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate

References

1. Patent US9040555 B2 2015-05-26.
2. Patent WO2021102161 A1 2021-05-27.
3. Prani Paka, et al. World J Nephrol. 2018 Sep 7;7(5):96-107.

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