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Chemical Structure : Antisauvagine-30
CAS No.: 220673-95-0
Catalog No.: PC-61274Not For Human Use, Lab Use Only.
Antisauvagine-30 is a potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist with Ki of 1.4 nM, 100-fold selectiivity over CRF1.
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|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
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Antisauvagine-30 is a potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist with Ki of 1.4 nM, 100-fold selectiivity over CRF1.
Antisauvagine-30 inhibits sauvagine-stimulated cAMP accumulation in HEK cells with pA2 of 8.49.
Antisauvagine-30 prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice.
| M.Wt | 3650.29 | |
| Formula | C161H274N48O46S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
FHLLRKMIEIEKQEKEKQQAANNRLLLDTI (Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide) |
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1. Rühmann A, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15264-9.
2. Sananbenesi F, et al. J Neurosci. 2003 Dec 10;23(36):11436-43.
3. Brauns O, et al. Neuropharmacology. 2001 Sep;41(4):507-16.
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