Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Apafant
CAS No.: 105219-56-5
Catalog No.: PC-70045Not For Human Use, Lab Use Only.
Apafant (WEB2086) is a potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Apafant (WEB2086) is a potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
Apafant (WEB2086) reverses or abolishes the bronchoconstriction, hypotension, thrombocytopenia and leukopenia induced by PAF-acether at 0.1-1 mg/kg in guinea-pigs.
Apafant (WEB2086) also markedly decreases the bronchoconstriction and leukopenia induced by 100 ug/kg antigen in mepyramine.
| M.Wt | 455.961 | |
| Formula | C22H22N5O2SCl | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl)-1-morpholinopropan-1-one |
|
1. Casals-Stenzel J, et al. J Pharmacol Exp Ther. 1987 Jun;241(3):974-81.
2. Casals-Stenzel J, et al. Br J Pharmacol. 1987 Aug;91(4):799-802.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
