Catalog No.: PC-70045Not For Human Use, Lab Use Only.
Apafant (WEB2086) is a potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
Apafant (WEB2086) is a potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
Apafant (WEB2086) reverses or abolishes the bronchoconstriction, hypotension, thrombocytopenia and leukopenia induced by PAF-acether at 0.1-1 mg/kg in guinea-pigs.
Apafant (WEB2086) also markedly decreases the bronchoconstriction and leukopenia induced by 100 ug/kg antigen in mepyramine.
