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Chemical Structure : Apararenone
CAS No.: 945966-46-1
Catalog No.: PC-35937Not For Human Use, Lab Use Only.
Apararenone (MT-3995) is a highly selective and potent, nonsteroidal mineralocorticoid receptor (MR) antagonist with Ki of 104 nM, >360-fold selectivity over GR,AR,PR and ER receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Apararenone (MT-3995) is a highly selective and potent, nonsteroidal mineralocorticoid receptor (MR) antagonist with Ki of 104 nM, >360-fold selectivity over GR,AR,PR and ER receptors.
Apararenone (MT-3995) exhibited a more potent antihypertensive and organ-protective activity than steroidal MRA eplerenone in a primary aldosteronism rat model obtained by infusing aldosterone in uninephrectomized rats.
| M.Wt | 364.391 | |
| Formula | C17H17FN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide |
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1. Kolkhof P, et al. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24.
2. Kolkhof P, et al. J Endocrinol. 2017 Jul;234(1):T125-T140.
3. Iijima T, et al. J Med Chem. 2022 Jun 2. doi: 10.1021/acs.jmedchem.2c00402.
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